US Patent No. 9,969,809

THERAPEUTIC ANTIBODIES AND THEIR USES


Patent No. 9,969,809
Issue Date May 15, 2018
Title Therapeutic Antibodies And Their Uses
Inventorship Tracy Chia-Chien Kuo, San Mateo, CA (US)
Javier Fernando Chaparro Riggers, San Mateo, CA (US)
Wei Chen, Cupertino, CA (US)
Amy Shaw-Ru Chen, San Jose, CA (US)
Edward Derrick Pascua, Oakland, CA (US)
Thomas John Van Blarcom, Oakland, CA (US)
Leila Marie Boustany, Redwood City, CA (US)
Weihsien Ho, Belmont, CA (US)
Yik Andy Yeung, South San Francisco, CA (US)
Pavel Strop, San Mateo, CA (US)
Arvind Rajpal, San Francisco, CA (US)
Assignee PFIZER INC., New York, NY (US)

Claim of US Patent No. 9,969,809

1. A bispecific antibody wherein the bispecific antibody is a full-length antibody, comprising a first antibody variable domain of the bispecific antibody capable of recruiting the activity of a human immune effector cell by specifically binding to an effector antigen located on the human immune effector cell, and comprising a second antibody variable domain of the bispecific antibody capable of specifically binding to a target antigen, wherein the first antibody variable domain comprises a heavy chain variable (VH) region comprising a VH CDR1, VH CDR2, and VH CDR3 of the VH sequence shown in SEQ ID NO: 320, 322, 324, 326, 328, 330, 345, 347, 349, 351, 444, 354, 356, 378, 442, 380, 382, 384 386, 388, 390, 392, 394, 396, 398, or 400; and e a light chain variable (VL) region comprising VL CDR1, VL CDR2, and VL CDR3 of the VL sequence shown in SEQ ID NO: 319, 321, 323, 325, 327, 329, 344, 346, 348, 350, 352, 355, 377, 443, 445, 379, 381, 383, 385, 387, 389, 391, 393, 395, 397, or 399.