US Patent No. 9,950,054

GLYCOCONJUGATION PROCESSES AND COMPOSITIONS


Patent No. 9,950,054
Issue Date April 24, 2018
Title Glycoconjugation Processes And Compositions
Inventorship Jianxin Gu, River Edge, NJ (US)
Jin-hwan Kim, Suffern, NY (US)
Avvari Krishna Prasad, Chapel Hill, NC (US)
Yu-ying Yang, Stamford, CT (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,950,054

1. A method of preventing, treating or ameliorating a bacterial infection, disease or condition in a subject, comprising administering to the subject an immunologically effective amount of an immunogenic glycoconjugate composition comprising a bacterial capsular polysaccharide conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, wherein the polysaccharide is covalently linked to the eTEC spacer through a carbamate linkage, and wherein the carrier protein is covalently linked to the eTEC spacer through an amide linkage.