US Patent No. 9,939,449

DIAGNOSTIC AND THERAPEUTIC METHODS AND PRODUCTS RELATED TO ANXIETY DISORDERS


Patent No. 9,939,449
Issue Date April 10, 2018
Title Diagnostic And Therapeutic Methods And Products Related To Anxiety Disorders
Inventorship Victor May, Essex, VT (US)
Kerry J. Ressler, Atlanta, GA (US)
Sayamwong E. Hammack, Essex Junction, VT (US)
Donna Toufexis, So. Burlington, VT (US)
Karen M. Braas, Essex, VT (US)
Assignee The University of Vermont and State Agricultural College, Burlington, VT (...

Claim of US Patent No. 9,939,449

1. A method for diagnosing and treating post traumatic stress disorder (PTSD) in a female human, comprising:a) analyzing pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in a tissue sample collected from a female human;
b) diagnosing PTSD in the female human having elevated tissue PACAP expression levels as compared to a control tissue sample obtained from a subject who does not have PTSD; and
c) administering to the female human diagnosed in (b) a therapeutically effective amount of an antibody that binds specifically to an epitope at the carboxy-terminal end of PACAP.