US Patent No. 9,937,150

METHOD FOR ENHANCING THE OXYGENATION LEVEL OF TISSUE CELLS AS AN ALTERNATIVE METHOD FOR HYPERBARIC OXYGEN THERAPY


Patent No. 9,937,150
Issue Date April 10, 2018
Title Method For Enhancing The Oxygenation Level Of Tissue Cells As An Alternative Method For Hyperbaric Oxygen Therapy
Inventorship Chia-Chen Wang, Kaohsiung (TW)
Wei-Ren Chen, Kaohsiung (TW)
Assignee National Sun Yat-sen University, Kaohsiung (TW)

Claim of US Patent No. 9,937,150

1. A method for substituting for or acting with a hyperbaric oxygen therapy (HBOT) to treat hypoxia, comprising the step of: administering a phthalide compound in combination with 2,3-bisphosphorglycerate to a subject in need thereof to increase oxygen release efficiency of hemoglobin (Hb) in the subject, wherein the subject is a subject treated by the hyperbaric oxygen therapy or a subject who needs to be treated by the hyperbaric oxygen therapy, wherein the phthalide compound is selected from the group consisting of Z-butylidenephthalide, Z-ligustilide, senkyunolide A, senkyunolide H, senkyunolide I, senkyunolide F, E-butylidenephthalide, E-ligustilide, 3-butylphthalide, 3-butylidene-4-hydrophthalide, 6,7-dihydroxyligustilide and 6,7-epoxyligustilide.