US Patent No. 9,913,862

METHODS OF TREATING GRAM-NEGATIVE MICROBIAL INFECTIONS


Patent No. 9,913,862
Issue Date March 13, 2018
Title Methods Of Treating Gram-negative Microbial Infections
Inventorship James J. Collins, Newton, MA (US)
J. Ruben Morones-Ramirez, Nuevo Leon (MX)
Jonathan Alexander Winkler, Brighton, MA (US)
Catherine S. Spina, Boston, MA (US)
Assignee Trustees of Boston University, Boston, MA (US)

Claim of US Patent No. 9,913,862

16. A pharmaceutical composition for treatment of a microbial infection comprising daptomycin in an amount that is not effective
by itself to treat the microbial infection, and a potentiating amount of a silver-containing compound, with a pharmaceutically
acceptable carrier, wherein the potentiating amount of the silver-containing compound is sufficient to expand the spectrum
of daptomycin, but is below a threshold level required to effectively treat the microbial infection when used alone.