US Patent No. 9,872,913

DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME


Patent No. 9,872,913
Issue Date January 23, 2018
Title Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
Inventorship Greg Troiano, Pembroke, MA (US)
Michael Figa, Allston, MA (US)
Abhimanyu Sabnis, Arlington, MA (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,872,913

1. A method of preparing a plurality of therapeutic nanoparticles, comprising:
combining a therapeutic agent, a first polymer bound to a ligand, and a second polymer, with an organic solvent to form a
first organic phase having about 5 to about 50% solids;

combining the first organic phase with a first aqueous solution to form a second phase;
emulsifying the second phase to form an emulsion phase;
quenching the emulsion phase to form a quenched phase at least partially at a temperature of 5° C. or less;
adding a drug solubilizer to the quenched phase to form a solubilized phase of unencapsulated therapeutic agent; and
sterile filtering the solubilized phase to recover the therapeutic nanoparticles, thereby forming a slurry of therapeutic
nanoparticles having a diameter of about 80 nm to about 150 nm.