US Patent No. 9,850,301

ANTIBODY TO GDF8 AND USES THEREOF


Patent No. 9,850,301
Issue Date December 26, 2017
Title Antibody To Gdf8 And Uses Thereof
Inventorship Edward Roland LaVallie, Harvard, MA (US)
Lisa Anne Collins-Racie, Acton, MA (US)
Christopher John Corcoran, Arlington, MA (US)
Lioudmila Gennadievna Tchistiakova, Andover, MA (US)
John Adam Nowak, Stratham, NH (US)
Riyez Karim, North Andover, MA (US)
Xiang-Yang Tan, Reading, MA (US)
Kimberly Ann Marquette, Somerville, MA (US)
Geertruida Machteld Veldman, Sudbury, MA (US)
Assignee PFIZER INC., New York, NY (US)

Claim of US Patent No. 9,850,301

1. An isolated polynucleotide comprising a nucleic acid sequence encoding at least one polypeptide chain of an antibody or
antigen binding fragment thereof that specifically binds GDF-8, said antibody or fragment comprising:
an antibody variable heavy (VH) region comprising the first, second and third complementarity determining regions (CDRs) from
the VH region defined by the amino acid sequence of SEQ ID NO:14 or SEQ ID NO:17; and

an antibody variable light (VL) region comprising the first, second and third CDRs from the VL region defined by the amino
acid sequence of SEQ ID NO:16 or SEQ ID NO:18.