US Patent No. 9,834,757

HAND, FOOT, AND MOUTH VACCINES AND METHODS OF MANUFACTURE AND USE THEREOF


Patent No. 9,834,757
Issue Date December 05, 2017
Title Hand, Foot, And Mouth Vaccines And Methods Of Manufacture And Use Thereof
Inventorship Subash Chandra Das, Middleton, WI (US)
Joseph David Santangelo, Helios (SG)
Dan Thomas Stinchcomb, Fort Collins, CO (US)
Jorge E. Osorio, Mount Horeb, WI (US)
Assignee Takeda Vaccines, Inc., Cambridge, MA (US)

Claim of US Patent No. 9,834,757

5. A hand, foot, and mouth immunogenic composition comprising at least one intact, inactivated virus that causes hand, foot
and mouth disease in humans and a detergent in an effective concentration, wherein:
a. the at least one intact, inactivated virus was inactivated with BEI;
b. the composition does not comprise an adjuvant, or comprises an aluminum salt adjuvant; or
c. (a) and (b).