5. A hand, foot, and mouth immunogenic composition comprising at least one intact, inactivated virus that causes hand, foot
and mouth disease in humans and a detergent in an effective concentration, wherein:
a. the at least one intact, inactivated virus was inactivated with BEI;
b. the composition does not comprise an adjuvant, or comprises an aluminum salt adjuvant; or
c. (a) and (b).