US Patent No. 9,751,937

ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR


Patent No. 9,751,937
Issue Date September 05, 2017
Title Antagonist Antibodies Against Gdf-8 And Uses Therefor
Inventorship Michelle M. Mader, Clayton, NC (US)
James R. Apgar, Somerville, MA (US)
Kevin D. Parris, Groton, CT (US)
Assignee PFIZER INC., New York, NY (US)

Claim of US Patent No. 9,751,937

1. A method of increasing the mass or strength of a muscle of a mammal, comprising administering to a mammal a therapeutically
effective amount of an antibody or antigen binding fragment thereof that specifically binds GDF-8, said antibody or fragment
comprising:
an antibody variable heavy (VH) region comprising first, second and third complementarity determining regions (CDR), wherein
VH CDR1 comprises SEQ ID NO:10 or SEQ ID NO:20, VH CDR2 comprises SEQ ID NO:11 or SEQ ID NO:21, and VH CDR3 comprises SEQ
ID NO:12; and

an antibody variable light (VL) region comprising first, second and third complementarity determining regions (CDR), wherein
VL CDR1 comprises SEQ ID NO:13, VL CDR2 comprises SEQ ID NO:14, and VL CDR3 comprises SEQ ID NO:15;

wherein said VH region comprises leucine at the amino acid position corresponding to residue number 111 of SEQ ID NO:44 (Kabat
position 108).