US Patent No. 9,751,895

N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4A,5,6-TETRAHYDROPYRANO[3,4-D][1,3]THIAZIN-8A(8H)-YL)-1,3-THIAZOL-4-YL]AMIDES


Patent No. 9,751,895
Issue Date September 05, 2017
Title N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl)-1,3-thiazol-4-yl]amides
Inventorship Michael Aaron Brodney, Newton, MA (US)
Christopher Ryan Butler, Canton, MA (US)
Lei Zhang, Auburndale, MA (US)
Patrick Robert Verhoest, Newton, MA (US)
Peter Justin Mikochik, Pawcatuck, CT (US)
John Charles Murray, East Lyme, CT (US)
Xinjun Hou, Winchester, MA (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,751,895

1. The compound of of Formula la

or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer;
wherein
R1 is a C5-9bicycloalkyl; and

R2 and R3 are each independently selected from C1-6alkyl or C3-7cycloalkyl; wherein the C1-6alkyl is optionally substituted with one to three fluoro or C1-3alkoxy; or R2 and R3 taken together with the carbon to which they are attached form a C3-6cycloalkyl ring or a 4-to 6-membered heterocycloalkyl ring, each of which is optionally and independently substituted with
one to three fluoro, C1-3alkyl or C1-3alkoxy.