US Patent No. 9,713,638

COMPOSITIONS AND METHODS FOR RAPID IMMUNIZATION AGAINST DENGUE VIRUS


Patent No. 9,713,638
Issue Date July 25, 2017
Title Compositions And Methods For Rapid Immunization Against Dengue Virus
Inventorship Dan T. Stinchcomb, Fort Collins, CO (US)
Jorge E. Osorio, Mount Horeb, WI (US)
Charalambos D. Partidos, Chicago, IL (US)
Joseph N. Brewoo, Madison, WI (US)
Assignee Takeda Vaccines, Inc., Deerfield, IL (US)

Claim of US Patent No. 9,713,638

1. A method for inducing an immune response in a subject against three or more dengue virus serotypes, the method comprising:
administering a first immunogenic composition of three or more live, attenuated dengue viruses, the composition comprising
at least one non-chimeric live, attenuated dengue-2 virus and at least one dengue-dengue chimera having a live, attenuated
dengue-2 virus backbone; and

administering a second immunogenic composition of three or more live, attenuated dengue viruses, the composition comprising
at least one of a non-chimeric live, attenuated dengue-2 virus and a dengue-dengue chimera having a live, attenuated dengue-2
virus backbone;

wherein the first immunogenic composition and the second immunogenic composition are administered subcutaneously at two or
more anatomical locations consecutively on the same day to the subject; and

inducing an immune response in the subject against the three or more dengue virus serotypes.