US Patent No. 9,708,405

ANTI-CXCR4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES


Patent No. 9,708,405
Issue Date July 18, 2017
Title Anti-cxcr4 Antibodies And Antibody-drug Conjugates
Inventorship Shu-Hui Liu, Redwood City, CA (US)
Flavia Mercer Pernasetti, San Diego, CA (US)
Wei-Hsien Ho, Belmont, CA (US)
Assignee PFIZER INC., New York, NY (US)

Claim of US Patent No. 9,708,405

1. An isolated antibody, or an antigen binding fragment thereof, that binds to chemokine receptor 4 (CXCR4) and comprises:
a) a heavy chain variable (VH) region comprising (i) a VH CDR1 selected from the group consisting of SEQ ID NOs:107, 113 and
114; (ii) a VH CDR2 selected from the group consisting of SEQ ID NOs: 162 and 128; and (iii) a VH CDR3 set forth as SEQ ID
NO: 112; and

b) a light chain variable region (VL) region comprising (i) a VL CDR1 set forth as SEQ ID NO: 144; (ii) a VL CDR2 set forth
as SEQ ID NO: 145; and (iii) a VL CDR3 set forth as SEQ ID NO: 139.