US Patent No. 9,657,089

DIAGNOSTIC ANTIBODY ASSAY


Patent No. 9,657,089
Issue Date May 23, 2017
Title Diagnostic Antibody Assay
Inventorship Jens-Ulrich Rahfeld, Gemeinde Seegebiet Mansfelder Land (DE)
Kristin Ebermann, Zittau (DE)
Assignee

Claim of US Patent No. 9,657,089

1. A method of treatment, alleviating the effects, or delay of a neurodegenerative disease in a subject comprising:
(A) administering of a pharmaceutically effective dose of an isolated monoclonal antibody to a subject in need thereof; or
(B) administering of a pharmaceutically effective dose of a pharmaceutical composition comprising an isolated monoclonal antibody
in combination with at least one pharmaceutically acceptable carrier or excipient to a subject in need thereof;

wherein
the neurodegenerative disease is selected from the group consisting of mild cognitive impairment, Alzheimer's disease, a Familial
Alzheimer's dementia, and neurodegeneration in Down Syndrome;

the monoclonal antibody binds to A? peptides between amino acid position 11 and an N-terminal pyroglutamate, A?pGlu(11), or
variants thereof;

the monoclonal antibody has a dissociation constant (KD) value of 10?7 or less, and

the variable part of the light chain of the antibody has the nucleotide sequence of SEQ ID NO: 51 or the amino acid sequence
of SEQ ID NO: 52.