US Patent No. 9,650,402

HETERODINUCLEAR PLATINUM-RUTHENIUM COMPLEXES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF


Patent No. 9,650,402
Issue Date May 16, 2017
Title Heterodinuclear Platinum-ruthenium Complexes, Preparation Thereof And Therapeutic Use Thereof
Inventorship Guangyu Zhu, Mid-Level West (HK)
Lili Ma, Kowloon Tong (HK)
Assignee CITY UNIVERSITY OF HONG KONG, Kowloon (HK)

Claim of US Patent No. 9,650,402

1. A heterodinuclear platinum and ruthenium (Pt¬óRu) complex having a chemical structure of Structure I:

wherein X1, X2, X?, X?, Y?, Y?, Z, Z? are electron donor ligands selected from a group consisting of: nitrogen (N)-containing ligands, oxygen
(O)-containing ligands, phosphorous (P)-containing ligands, sulfur (S)-containing ligands, and halogens,

wherein Y is pyridine,
wherein A is an arene,
wherein W is a linker unit with any length to link Y and Z together, and
wherein n is 0, any positive or negative value.