US Patent No. 9,607,818

MULTIMODE IONIZATION DEVICE


Patent No. 9,607,818
Issue Date March 28, 2017
Title Multimode Ionization Device
Inventorship Jentaie Shiea, Kaohsiung (TW)
Assignee National Sun Yat-Sen University, Kaohsiung (TW)

Claim of US Patent No. 9,607,818

1. A multimode ionization device adapted for a mass spectrometer which includes a receiving unit disposed to admit therein
ionized analytes that are derived from a sample, and that are to be analyzed by the mass spectrometer, said multimode ionization
device comprising:
an electrospray unit including a reservoir for providing a liquid electrospray medium, and a nozzle which is disposed downstream
of said reservoir and which is configured to form an electrospray plume of the liquid electrospray medium thereat, said nozzle
being disposed to be spaced apart from the receiving unit so as to define a traveling path therebetween;

a charge generating unit configured to laden the liquid electrospray medium with a plurality of charges when the liquid electrospray
medium runs up to said nozzle, thereby permitting the liquid electrospray medium to leave said nozzle as the electrospray
plume for heading toward the receiving unit to be admitted thereinto; and

a plasma supplying unit configured to generate and guide a plasma plume to mix with the electrospray plume so as to form a
plume combination in a confluent zone which is upstream of a linearly-extending end zone of the traveling path, and which
is oriented to permit at least one of analytes carried in the plume combination to travel to the receiving unit along the
linearly-extending end zone, such that as a result of approaching the receiving unit along the linearly-extending end zone,
charges of the plume combination will pass on to said at least one of the analytes carried in the plume combination to thereby
form a corresponding one of the ionized analytes,

wherein said charge generating unit includes
an ion generating chamber having an outlet disposed upstream of said nozzle, and an inner surface having a material, and
a source of high velocity gas disposed to fluidly communicate with said inner surface to permit a physical interaction between
the high velocity gas and said material to produce the charges for the liquid electrospray medium to be ladened therewith.