1. A lyophilized probiotic composition comprising an effective amount of Rothia species bacteria and a pharmaceutically acceptable carrier, wherein the bacteria comprises a gluten-degrading enzyme that
retains protease activity at acidic pH of 3.0 as measured in an in vitro gliadin degradation assay for 3 hours using a synthetic
substrate Z-YPQ-pNA, wherein the enzyme, when purified, comprises an iso-electric point within a pH range of 2.0-7.0 inclusive,
and wherein the composition is formulated into granules.