US Patent No. 9,597,347

COMPOSITIONS FOR TREATING OBESITY AND INSULIN RESISTANCE DISORDERS


Patent No. 9,597,347
Issue Date March 21, 2017
Title Compositions For Treating Obesity And Insulin Resistance Disorders
Inventorship David A. Sinclair, Chestnut Hill, MA (US)
Maria Alexander-Bridges, West Newton, MA (US)
Assignee President and Fellows of Harvard College, Cambridge, MA (US) The General H...

Claim of US Patent No. 9,597,347

1. A method for treating an insulin resistance disorder in a subject in need thereof, comprising administering to the subject
nicotinamide riboside or a nicotinamide riboside analog represented by formula A:

wherein R represents independently for each occurrence H, acetyl, benzoyl, acyl, phosphate, sulfate, (alkyoxy)methyl, triarylmethyl,
(trialkyl)silyl, (dialkyl)(aryl)silyl,

(alkyl)(diaryl)silyl, or (triaryl)silyl; and X represents 0 or S, at a concentration of 1 nM to 10 ?M,
wherein the subject is a human subject.