US Patent No. 9,579,386

DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME


Patent No. 9,579,386
Issue Date February 28,2017
Title Drug Loaded Polymeric Nanoparticles And Methods Of Making And Using Same
Inventorship Stephen E. Zale, Hopkinton, MA (US)
Greg Troiano, Pembroke, MA (US)
Mir Mukkaram Ali, Woburn, MA (US)
Jeff Hrkach, Lexington, MA (US)
James Wright, Lexington, MA (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,579,386

1. A therapeutic nanoparticle comprising:
about 4 to about 25 weight percent of a therapeutic agent;
about 10 to about 99 weight percent of a diblock poly(lactic) acid-poly(ethylene)glycol copolymer comprising poly(lactic)
acid having a number average molecular weight of about 15 to 20 kDa, and poly(ethylene)glycol having a number average molecular
weight of about 4 to 6 kDa;

wherein the hydrodynamic diameter of the therapeutic nanoparticle is about 60 nm to about 140 nm; and
wherein the therapeutic nanoparticles releases less than 2% of the therapeutic agent over about one minute when placed in
a phosphate buffer solution at 37° C.