US Patent No. 9,428,577

PLATELET-DERIVED GROWTH FACTOR B SPECIFIC ANTIBODIES AND COMPOSITIONS AND USES THEREOF


Patent No. 9,428,577
Issue Date August 30, 2016
Title Platelet-derived Growth Factor B Specific Antibodies And Compositions And Uses Thereof
Inventorship Robert Arch, Saint Louis, MO (US)
Gregory Carven, Maynard, MA (US)
Jun Kuai, Lexington, MA (US)
Lydia Mosyak, Newton, MA (US)
Shinji Ogawa, Setagaya (JP)
Dirk Ponsel, Germering (DE)
Robert Rauchenberger, Farchant (DE)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,428,577

1. An isolated antibody, or antigen-binding fragment thereof, that specifically binds PDGF-B and comprises:
a VH comprising the CDR-H1 amino acid sequence of SEQ ID NO:7, the CDR-H2 amino acid sequence of SEQ ID NO:8, and the CDR-H3 amino
acid sequence of SEQ ID NO: 9; and

a VL comprising the CDR-L1 amino acid sequence of SEQ ID NO:10, the CDR-L2 amino acid sequence of SEQ ID NO:11, and the CDR-L3
amino acid sequence of SEQ ID NO:12.