US Patent No. 9,393,288

METHODS OF TREATING DISEASES ASSOCIATED WITH PPAR?


Patent No. 9,393,288
Issue Date July 19, 2016
Title Methods Of Treating Diseases Associated With Ppar?
Inventorship Marilyn J. Cipolla, Colchester, VT (US)
Assignee The University of Vermont and State Agricultural College, Burlington, VT (...

Claim of US Patent No. 9,393,288

1. A method for treating a small vessel disease of the brain, comprising
identifying a subject as having a small vessel disease of the brain and chronically administering to the subject having the
small vessel disease of the brain a relaxin or agonist thereof, wherein the subject is not otherwise in need of treatment
with relaxin or agonist thereof in an effective amount to promote outward remodeling of the small vessels of the brain, wherein
the small vessel disease of the brain is due to hypertension and wherein the relaxin or agonist thereof crosses the blood
brain barrier.