US Patent No. 9,359,410


Patent No. 9,359,410
Issue Date June 07, 2016
Title Virus Like Particle Purification
Inventorship Thomas S. Vedvick, Bozeman, MT (US)
Bryan Steadman, Bozeman, MT (US)
Charles Richardson, Bozeman, MT (US)
Thomas R. Foubert, Bozeman, MT (US)
Charles R. Petrie, Bozeman, MT (US)
Assignee TAKEDA VACCINES INC., Bozeman, MT (US)

Claim of US Patent No. 9,359,410

1. A method of purifying Calicivirus virus-like particles (VLPs) comprising contacting a solution containing said VLPs with
at least one chromatographic material, wherein the at least one chromatographic material is an ion exchange chromatographic
material, wherein the chromatographic materials used in the method do not comprise hydroxyapatite, and wherein the VLPs are
purified to greater than about 70%.