US Patent No. 9,308,249


Patent No. 9,308,249
Issue Date April 12, 2016
Title Norovirus Vaccine Formulations
Inventorship Charles Richardson, Bozeman, MT (US)
Thomas S. Vedvick, Federal Way, WA (US)
Thomas R. Foubert, Bozeman, MT (US)
William T. Tino, Belgrade, MT (US)
Assignee TAKEDA VACCINES, INC., Bozeman, MT (US)

Claim of US Patent No. 9,308,249

1. An immunogenic composition comprising at least one Norovirus antigen and an effective amount of at least one adjuvant,
wherein the adjuvant is a toll-like receptor (TLR) agonist that is not a bacterial exotoxin, wherein said antigen comprises
Norovirus virus-like particles (VLPs), and wherein the composition is formulated as a stable dry powder, wherein the percent
aggregation of VLPs in the composition remains constant or decreases when measured over a twelve month period.