US Patent No. 9,278,953

ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR


Patent No. 9,278,953
Issue Date March 08, 2016
Title Antagonists Of Prostaglandin Ep3 Receptor
Inventorship Kevin Barry Bahnck, Old Lyme, CT (US)
David James Edmonds, Arlington, MA (US)
Kentaro Futatsugi, Quincy, MA (US)
Esther Cheng Yin Lee, Brookline, MA (US)
Alan Martin Mathiowetz, Quaker Hill, CT (US)
Elnaz Menhaji-Klotz, Somerville, MA (US)
Robert Vernon Stanton, Belmont, MA (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,278,953

1. A compound of Formula I:

wherein
R1 is H, C1-6alkyl, or C3-6cycloalkyl;

m is 1 or 2;
Each R2 is independently halogen, C1-6alkyl, or C3-6cycloalkyl;

n is 0 or 1;
X1, X2, and X3 are independently ?N—, —NRXn—, or ?CRXc—, provided that at least 1 but no more than 2 of X1, X2, and X3 are independently ?N— or —NRXn—;

RXn is H, C1-6alkyl, or C3-6cycloalkyl; and

Each RXc is independently H, halogen, C1-6alkyl, or C3-6cycloalkyl;

or a pharmaceutically acceptable salt thereof.