US Patent No. 9,238,620

PHARMACEUTICAL USES OF SULFUR-CONTAINING COMPOUND


Patent No. 9,238,620
Issue Date January 19, 2016 
Title Pharmaceutical Uses Of Sulfur-containing Compound
Inventorship Chieh-Hsi Wu, Kaohsiung (TW)
Jyh-Horng Sheu, Kaohsiung (TW)
Chih-Yi Chen, Kaohsiung (TW)
Yi-Chung Chien, Kaohsiung (TW)
Shuo-Chueh Chen, Kaohsiung (TW)
Chun-Hsu Pan, Kaohsiung (TW)
Chiung-Yao Huang, Kaohsiung (TW)
Assignee NATIONAL SUN YAT-SEN UNIVERSITY, Kaohsiung (TW)

Claim of US Patent No. 9,238,620

1. A method for inhibiting lung cancer metastasis and/or growth comprising administering a subject with a compound represented
by the following general formula 1,

wherein:
R1 is selected from the group consisting of H, R5 and R5C(?O);

R2 is selected from the group consisting of S and (O?)S(?O);

R3 is selected from the group consisting of H, CH3 and CH2CH2C(?O)OR5;

R4 is selected from the group consisting of R5, OR5,

N(R5)2, NH2, NHR5 and OH; and
R5 is selected from an alkyl group having one to six carbon atoms and an unsubstituted or substituted phenyl group;

provided that when R3 is CH2CH2C(?O)OR5, R4 is OR5; and

when R1 is H, R2 is S and R3 is H, R4 is not CH3;
wherein the compound represented by the general formula 1 is selected from the group consisting of formulae 3, 6 to 9, and
18 to 20;