US Patent No. 9,221,915

HUMAN MONOCLONAL ANTIBODIES TO ACTIVIN RECEPTOR-LIKE KINASE-1


Patent No. 9,221,915
Issue Date December 29, 2015
Title Human Monoclonal Antibodies To Activin Receptor-like Kinase-1
Inventorship Shelley Sims Belouski, Camarillo, CA (US)
Michael Aidan North, Rancho Santa Fe, CA (US)
Karin Kristina Amundson, San Diego, CA (US)
Vahe Bedian, Framingham, MA (US)
Dana Dan Hu-Lowe, Encinitas, CA (US)
Xin Jiang, San Diego, CA (US)
Shannon Marie Karlicek, San Diego, CA (US)
James Arthur Thomson, San Diego, CA (US)
Jianying Wang, San Diego, CA (US)
Grant Raymond Wickman, San Diego, CA (US)
Jingchuan Zhang, Boulder, CO (US)
Assignee Pfizer Inc., New York, NY (US) Amgen Fremont Inc., Fremont, CA (US)

Claim of US Patent No. 9,221,915

1. A method for treating cancer in a human in need thereof, comprising the step of administering to said human an anti-activin
receptor-like kinase-1 (ALK-1) antibody or an antigen-binding portion thereof, wherein said antibody comprises the heavy chain
CDR1-3 and the light chain CDR1-3 found in the following amino acid sequences, respectively:
a) SEQ ID NO: 6 and SEQ ID NO: 8;
b) SEQ ID NO: 14 and SEQ ID NO: 16;
c) SEQ ID NO: 18 and SEQ ID NO: 20;
d) SEQ ID NO: 26 and SEQ ID NO: 28;
e) SEQ ID NO: 30 and SEQ ID NO: 32;
f) SEQ ID NO: 38 and SEQ ID NO: 40;
g) SEQ ID NO: 46 and SEQ ID NO: 48;
h) SEQ ID NO: 50 and SEQ ID NO: 52;
i) SEQ ID NO: 54 and SEQ ID NO: 56;
j) SEQ ID NO: 58 and SEQ ID NO: 60;
k) SEQ ID NO: 62 and SEQ ID NO: 64;
l) SEQ ID NO: 66 and SEQ ID NO: 68; or
m) SEQ ID NO: 70 and SEQ ID NO: 72.