US Patent No. 9,211,323

COMPOSITIONS AND METHODS FOR ADMINISTRATION OF VACCINES AGAINST DENGUE VIRUS


Patent No. 9,211,323
Issue Date December 15, 2015
Title Compositions And Methods For Administration Of Vaccines Against Dengue Virus
Inventorship Dan T. Stinchcomb, Fort Collins, CO (US)
Jorge E. Osorio, Mount Horeb, WI (US)
Charalambos D. Partidos, Chicago, IL (US)
Joseph N. Brewoo, Madison, WI (US)
Assignee TAKEDA VACCINES, INC., Deerfield, IL (US)

Claim of US Patent No. 9,211,323

1. A method for inducing an immune response in a subject against three or more dengue virus serotypes, comprising,
administering to the subject by at least a first intradermal introduction, a first immunogenic composition of a mixture of
three or more live, attenuated dengue viruses, the composition comprising at least one dengue-dengue chimera and three or
more different dengue virus serotype in the mixture, and administering at least a second intradermal introduction(s) of a
second immunogenic composition against one or more dengue virus serotypes within 30 days after the first administration of
the first immunogenic composition to the subject and inducing an immune response in the subject against three or more dengue
virus serotypes.