US Patent No. 9,145,427

TRIAZINE DERIVATIVES


Patent No. 9,145,427
Issue Date September 29, 2015
Title Triazine Derivatives
Inventorship Thomas Allen Chappie, Carlisle, MA (US)
Christopher John Helal, Mystic, CT (US)
Bethany Lyn Kormos, Somerville, MA (US)
Jamison Byrce Tuttle, Marblehead, MA (US)
Patrick Robert Verhoest, Newton, MA (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,145,427

1. A compound of the formula:
or a pharmaceutically acceptable salt thereof, in which:
A, along with X and the carbon atom to which it is attached, forms a (C6-C10)aryl or a 5- to 10-membered heteroaryl moiety, in which said aryl or heteroaryl moiety is optionally substituted with up
to 4 substituents, each independently selected from the group consisting of C3-C6 cycloalkyl, oxo, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, hydroxy, cyano, halo, —NR5R6, —C(O)—NR5R6, —NH—C(O)R5, —C(O)—OR5, —(C1-C6)alkyl-(C3-C6)cycloalkyl, a 4- to 6-membered heterocyclic moiety, phenyl, and benzyl;

X is represented by N or C, and
R5 and R6 are each optionally and independently represented by hydrogen or C1-C6 alkyl.