US Patent No. 9,066,898

PROSTATE-ASSOCIATED ANTIGENS AND VACCINE-BASED IMMUNOTHERAPY REGIMENS


Patent No. 9,066,898
Issue Date June 30, 2015
Title Prostate-associated Antigens And Vaccine-based Immunotherapy Regimens
Inventorship Joseph John Binder, San Diego, CA (US)
Helen Kim Cho, San Diego, CA (US)
Michael Robert Dermyer, Carlsbad, CA (US)
Karin Ute Jooss, San Diego, CA (US)
Brian Gregory Pierce, Wayland, MA (US)
Joyce Tsi Tan, Chapel Hill, NC (US)
Van To Tsai, San Diego, CA (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 9,066,898

1. A multi-antigen construct that comprises:
(a) at least one nucleotide sequence encoding an immunogenic PSA polypeptide;
(b) at least one nucleotide sequence encoding an immunogenic PSCA polypeptide; and
(c) at least one nucleotide sequence encoding an immunogenic PSMA polypeptide, wherein the immunogenic PSA polypeptide comprises
amino acids 4-240 of SEQ ID NO:17, wherein the immunogenic PSCA polypeptide comprises the amino acid sequence of SEQ ID NO:21,
and wherein the immunogenic PSMA polypeptide has at least 90% identity with amino acids 15-750 of the human PSMA of SEQ ID
NO:1 and comprises the amino acids of at least 10 conserved T cell epitopes of the human PSMA at corresponding positions.