1. A compound of Formula I,
wherein
R1 is hydrogen or methyl, wherein said methyl is optionally substituted with one to three substituents independently selected
from halogen or methoxy;

R2 is C1-6 alkyl, —(C(R5)2)m—(C3-6 cycloalkyl), —C(R5)2)m—(C6-10 aryl), —(C(R5)2)m— (5- to 10-membered heteroaryl) or —(C(R5)2)t—OR6; wherein said alkyl, cycloalkyl, aryl or heteroaryl moieties are optionally substituted with one to three substituents independently
selected from halogen, C1-6 alkyl, —CH2F, —CHF2, —CF3, —CN or —OR7;

R3 is —C(R5)2)m—(CN);

R4 is independently selected from halogen, C1-6 alkyl or C1-6 alkoxy; wherein said alkyl or alkoxy is optionally substituted with one to three fluoro;

R5 at each occurrence is independently selected from hydrogen or C1-3 alkyl, wherein said alkyl is optionally substituted with one to three halogen;

R6 is hydrogen, C1-6 alkyl or —C(R5)2)n—(C6-10 aryl), wherein said alkyl and aryl are optionally substituted with one to three substituents independently selected from halogen,
C1-3 alkyl, —CH2F, —CHF2, —CF3, —CN or —OH;

R7 for each occurrence is hydrogen or C1-6 alkyl, wherein said alkyl is optionally substituted with one to three substituents independently selected from halogen or
C1-6 alkoxy;

m at each occurrence is independently 0, 1 or 2;
n at each occurrence is independently is 1 or 2;
t is 1 or 2; and
x is 0, 1, 2 or 3;
or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.