1. A tube and fitting system for use in a liquid chromatography system, comprising:a tube configured to be inserted into a receiving cavity of a fluidic device, the tube having a passageway therethrough opening at a front side of the tube, the tube comprising:
i) an outer tubing; and
ii) a biocompatible inner tubing having the passageway therethrough and being located within the outer tubing and extending to the front side,
a first sealing element comprising a polymer and surrounding the tube including at the front side, wherein the first sealing element provides a sealing to the inner tubing and is configured to seal the receiving cavity at the front side; and
a fitting configured to couple the tube to the fluidic device, the fitting comprising a back ferrule and a front ferrule, the front ferrule comprising a tapered portion, wherein:
the back ferrule comprises a metal, and the front ferrule comprises a polymer; and
the back ferrule is configured to hold the tube by the outer tubing, and the front ferrule is configured to seal the receiving cavity along a lateral side of the tube.