US Patent No. 10,987,010

SYSTEMS AND METHODS FOR VASCULAR DIAGNOSIS USING BLOOD FLOW MAGNITUDE AND/OR DIRECTION


Patent No. 10,987,010
Issue Date April 27, 2021
Title Systems And Methods For Vascular Diagnosis Using Blood Flow Magnitude And/or Direction
Inventorship Leo J. Grady, Millbrae, CA (US)
Charles A. Taylor, Menlo Park, CA (US)
Assignee HeartFlow, Inc., Redwood City, CA (US)

Claim of US Patent No. 10,987,010

1. A computer-implemented method of determining blood flow deviation in a patient's vasculature, the method comprising:receiving an electronic representation of a reference vasculature from a population-based healthy blood flow vasculature or a population-based diseased blood flow vasculature;
receiving a patient-specific model of a patient's vasculature representing a patient-specific healthy blood flow vasculature or a patient-specific diseased blood flow vasculature, wherein the patient's vasculature and the reference vasculature are of at least a common anatomical region and physiological state;
determining a reference blood flow direction at a location in the reference vasculature using the electronic representation of the reference vasculature;
simulating a blood flow through the patient-specific model;
computing a simulated patient-related blood flow direction at a location in the patient's vasculature corresponding to the location in the reference vasculature, using the simulated blood flow through the patient-specific model of the patient's vasculature, the reference vasculature being different from the patient vasculature;
determining a simulated patient-specific blood flow deviation, based on a calculated difference in direction between the reference blood flow direction of the reference vasculature at a plurality of locations and the simulated patient-related blood flow direction of the patient's vasculature corresponding to each of the plurality of locations; and
based on whether the simulated patient-specific blood flow deviation includes a statistical outlier based on the calculated difference at at least one of the plurality of locations, generating
a treatment recommendation for treating each of the plurality of locations of the simulated patient-specific blood flow having the deviation.