US Patent No. 10,920,278

METHOD TO TREAT HYPOTENSION USING VASOPRESSIN IN CERTAIN GENOTYPES


Patent No. 10,920,278
Issue Date February 16, 2021
Title Method To Treat Hypotension Using Vasopressin In Certain Genotypes
Inventorship Saji Vijayan, Chester Springs, PA (US)
Assignee PAR PHARMACEUTICAL, INC., Chestnut Ridge, NY (US)

Claim of US Patent No. 10,920,278

1. A method of increasing blood pressure to a target blood pressure in a human patient with post-cardiotomy shock wherein the patient has an LNPEP AA or AT rs4869317 genotype, the method comprising: intravenously administering to the patient a pharmaceutical formulation comprising vasopressin at a starting dose of 0.03 units/minute and titrating the dose up by 0.005 units/minute at 10 to 15 minute intervals to maintain the target blood pressure, wherein the maximum dose is 0.121 units/minute.