1. A method of producing D-psicose, comprising:subjecting D-fructose to D-psicose epimerization to produce a D-psicose-containing solution,
subjecting the D-psicose-containing solution to first cooling and ion exchange purification,
subjecting the purified D-psicose-containing solution to first concentration and second cooling,
subjecting the D-psicose-containing solution, which has been subjected to first concentration and second cooling, to chromatography to obtain a D-fructose-containing mother liquor and a D-psicose-containing separated solution, and
subjecting the D-psicose-containing separated solution to second concentration and third cooling to crystallize D-psicose and thereby obtaining D-psicose crystals produced through D-psicose crystallization and a mother liquor containing a remaining D-psicose,
wherein the D-fructose-containing mother liquor produced by chromatography is reused in the D-psicose epimerization, and
wherein the mother liquor containing the remaining D-psicose is reused in the first cooling and ion purification, the first concentration and second cooling, or the chromatography.