US Patent No. 10,919,930

ENHANCED PURIFICATION OF ANTIBODIES AND ANTIBODY FRAGMENTS BY APATITE CHROMATOGRAPHY


Patent No. 10,919,930
Issue Date February 16, 2021
Title Enhanced Purification Of Antibodies And Antibody Fragments By Apatite Chromatography
Inventorship Peter S. Gagnon, Singapore (SG)
Assignee Bio-Rad Laboratories, Inc., Hercules, CA (US)

Claim of US Patent No. 10,919,930

1. A method for purifying at least one non-aggregated antibody or at least one immunoreactive antibody fragment from an impure preparation containing said antibody or antibody fragment comprising the steps of (a) contacting the impure preparation with an apatite chromatography support and (b) eluting the antibody or antibody fragment with a sulfate as the primary eluting ion.