US Patent No. 10,918,746

RADIOACTIVE COMPOSITIONS AND METHODS FOR THEIR THERAPEUTIC USE


Patent No. 10,918,746
Issue Date February 16, 2021
Title Radioactive Compositions And Methods For Their Therapeutic Use
Inventorship David A Wilson, Lake Jackson, TX (US)
R. Keith Frank, Lake Jackson, TX (US)
Jaime Simon, Angleton, TX (US)
Druce K Crump, Lake Jackson, TX (US)
Assignee IsoTherapeutics Group LLC, Angleton, TX (US)

Claim of US Patent No. 10,918,746

1. A composition comprising a Non-Sealed, radioactive pharmaceutically-acceptable composition of the formulaQq—Tt—Cc—Rr  Formula (I)wherein:Q is a Substrate of a different material from Cc entity, wherein such Substrate has the Cc entity deposited or adhered thereto; and is an injectable or implantable Substrate that is either pharmaceutically-acceptable or can be Coated to be pharmaceutically-acceptable;
q is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;
T is a non-radioactive iron hydroxide, iron oxide, gadolinium hydroxide or gadolinium oxide;
t is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;
C is Sn(L)u—{Mw(OH)x(CO3)y·nH2O}p, wherein:
Sn is radioactive tin (IV)-117m but also contains non-radioactive tin isotopes;
L is hydrous oxide, hydroxide, or oxyhydroxide such that Sn(L)u is hydrous stannic oxide, stannic hydroxide, or stannic oxyhydroxide, or mixtures thereof;
u is greater than 0;
M is a Rare-earth Type Metal, or mixture thereof, wherein M can further include a radioactive Rare-earth Type Metal selected from the group consisting of Y-90, Sm-153, Ho-116, or Lu-177, or mixtures thereof;
w, x and y are each independently greater than 0;
n is greater than or equal to 0; and
p is equal to 1 or 0, wherein when p is 0, then at least one of q, t or r is 1;
c is equal to 1;
R is a Coat comprising a substance of a different composition than Cc entity, which covers Cc, and if q is 1, also Coats Substrate Q, and the resulting Coated composition is pharrnaceutically-acceptable for infection; and
r is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;
with the provisos that if either q or t is equal to 1, then the other is equal to 0; each of u, v, w, x, y and z are of a numeric value, fractional values included, such that electrical neutrality is attained; and n is greater than or equal to 0 to provide optional water of hydration.