US Patent No. 10,918,631

PHARMACEUTICAL COMPOSITIONS FOR DIRECT SYSTEMIC INTRODUCTION


Patent No. 10,918,631
Issue Date February 16, 2021
Title Pharmaceutical Compositions For Direct Systemic Introduction
Inventorship Mark Ridall, Pennington, NJ (US)
David Rock, California, MO (US)
Assignee NewMarket Pharmaceuticals LLC, Trenton, NJ (US)

Claim of US Patent No. 10,918,631

1. A method of making a pharmaceutical composition for direct system introduction, the composition comprising:about 10-17 dry mass % bovine gelatin,
about 10-17 dry mass % mannitol,
about 0-1 dry mass % of a surfactant,
about 0-0.5 dry mass % of a flavorant, and
about 65-80 dry mass % of an active pharmaceutical ingredient which is a proton pump inhibitor;wherein the method comprises:combining the active pharmaceutical ingredient with one or more pharmacologically inactive compound(s) to form a pre-formulation;
freezing the pre-formulation;
reducing the pressure surrounding the pre-formulation; and
lyophilizing the pre-formulation.