1. A method of making a pharmaceutical composition for direct system introduction, the composition comprising:about 10-17 dry mass % bovine gelatin,
about 10-17 dry mass % mannitol,
about 0-1 dry mass % of a surfactant,
about 0-0.5 dry mass % of a flavorant, and
about 65-80 dry mass % of an active pharmaceutical ingredient which is a proton pump inhibitor;wherein the method comprises:combining the active pharmaceutical ingredient with one or more pharmacologically inactive compound(s) to form a pre-formulation;
freezing the pre-formulation;
reducing the pressure surrounding the pre-formulation; and
lyophilizing the pre-formulation.