US Patent No. 10,835,597
COMPOSITIONS AND METHODS FOR STABILIZING FLAVIVIRUSES WITH IMPROVED FORMULATIONS
| Patent No. | 10,835,597 |
|---|---|
| Issue Date | November 17, 2020 |
| Title | Compositions And Methods For Stabilizing Flaviviruses With Improved Formulations |
| Inventorship | Jill Ann Livengood, Fort Collins, CO (US) Linda Marie Strange, Framingham, MA (US) Steven Michael Erb, Fort Collins, CO (US) |
| Assignee | TAKEDA VACCINES, INC., Cambridge, MA (US) |
Claim of US Patent No. 10,835,597
1. A flavivirus composition comprising:one or more live flaviviruses;
at least one of trehalose in a concentration ranging from 5.0% to 15.0% (w/v) and sucrose in a concentration ranging from 5.0% to 15.0% (w/v);
urea;
mannitol; and
human serum albumin.
at least one of trehalose in a concentration ranging from 5.0% to 15.0% (w/v) and sucrose in a concentration ranging from 5.0% to 15.0% (w/v);
urea;
mannitol; and
human serum albumin.