US Patent No. 10,806,781

COMPOSITIONS AND METHODS FOR LIVE, ATTENUATED ALPHAVIRUS FORMULATIONS


Patent No. 10,806,781
Issue Date October 20, 2020
Title Compositions And Methods For Live, Attenuated Alphavirus Formulations
Inventorship Dan T. Stinchcomb, Enumclaw, WA (US)
Jill A. Livengood, Fort Collins, CO (US)
Laszlo Varga, Fort Collins, CO (US)
Assignee Takeda Vaccines, Inc., Cambridge, MA (US)

Claim of US Patent No. 10,806,781

1. A live attenuated alphavirus virus composition comprising:one or more live, attenuated alphaviruses selected from the group consisting of chikungunya (CHIK) virus, o'nyong'nyong virus, Eastern equine encephalitis, Western equine encephalitis, and Venezuelan equine encephalitis;
10.0 to 20.0 mM HEPES buffer;
one or more carbohydrate agents having a concentration from 1.0% to 15% (w/v) selected from the group consisting of: trehalose, sucrose, mannitol, sorbitol, and galactose; and
0.1% to 1.0% (w/v) gelatin,wherein the composition stabilizes live attenuated alphavirus compositions.