1. A method of eliciting protective immunity to a Norovirus infection in a human comprising administering to the human a vaccine comprising at least two Norovirus virus-like particles (VLPs), wherein the at least two VLPs represent different Norovirus genotypes, wherein at least one Norovirus VLP is present in the vaccine in a dose amount of from about 1 ug to about 200 ug, and wherein the vaccine is able to elicit immunity against each Norovirus genotype represented in the vaccine.