US Patent No. 10,675,341

PARENTERAL NOROVIRUS VACCINE FORMULATIONS


Patent No. 10,675,341
Issue Date June 09, 2020
Title Parenteral Norovirus Vaccine Formulations
Inventorship Charles Richardson, Bozeman, MT (US)
Thomas R. Foubert, Bozeman, MT (US)
Assignee Takeda Vaccines, Inc., Cambridge, MA (US)

Claim of US Patent No. 10,675,341

1. A method of eliciting protective immunity against Norovirus in a human comprising administering parenterally to the human no more than a single dose of a vaccine composition, said composition comprising(i) genogroup I Norovirus virus-like particles (VLPs), wherein said genogroup I Norovirus VLPs comprise a capsid protein derived from a genogroup I viral strain, and
(ii) genogroup II Norovirus VLPs, wherein said genogroup II Norovirus VLPs comprise a capsid protein derived from a genogroup II viral strain,
wherein said genogroup I Norovirus VLPs and genogroup II Norovirus VLPs are present in the composition in different amounts, wherein said composition comprises about 15 ?g to 50 ?g of genogroup I Norovirus VLPs and about 50 ?g to 150 ?g of genogroup II Norovirus VLPs,
wherein said composition induces at least a three-fold increase in Norovirus-specific serum antibody titer as compared to the titer in the human prior to administration of the composition.