US Patent No. 10,655,126

METHODS AND COMPOSITIONS TO TREAT DRUG-INDUCED DISEASES AND CONDITIONS


Patent No. 10,655,126
Issue Date May 19, 2020
Title Methods And Compositions To Treat Drug-induced Diseases And Conditions
Inventorship Mercedes Rincon, Burlington, VT (US)
Maria Luz Martinez Chantar, Derio (ES)
Juan Anguita, Derio (ES)
Oliver Dienz, Shelburne, VT (US)
Assignee University of Vermont and State Agricultural College, Burlington, VT (US) ...

Claim of US Patent No. 10,655,126

1. A method for treating an acetaminophen-induced liver disease or condition in a subject, the method comprising administering to a subject in need of such treatment an MCJ-inhibiting compound in an amount effective to treat the acetaminophen-induced liver disease or condition in the subject, wherein the MCJ-inhibiting compound reduces MCJ polypeptide activity in the subject and decreasing the MCJ polypeptide activity comprises decreasing one or more of an MCJ polypeptide level or activity, and wherein the MCJ-inhibiting compound comprises am MCJ small interference RNA molecule (MCJ siRNA) or an MCJ small hairpin RNA molecule (MCJ shRNA).