US Patent No. 10,653,603

N-ACYLDIPEPTIDE DERIVATIVES AND THEIR USES


Patent No. 10,653,603
Issue Date May 19, 2020
Title N-acyldipeptide Derivatives And Their Uses
Inventorship Ruey J. Yu, Chalfont, PA (US)
Eugene J. Van Scott, Abington, PA (US)
Assignee NEOSTRATA COMPANY, INC., Princeton, NJ (US)

Claim of US Patent No. 10,653,603

1. A method of treating skin, comprising topically administering to skin in need of increased thickness or treatment for abnormal or diminished synthesis of collagen, glycosaminoglycans, proteoglycans, or elastin a composition comprising a therapeutically effective amount of a dipeptide derivative of formula (I):R1-AAB-AAC-R2   Formula (I)or an isomer or salt thereof, and optionally a pharmaceutically or cosmetically acceptable carrier, wherein R1 is an acyl radical having up to 19 carbon atoms; AAB is Tyr and AAC is Tyr, or AAB is Val and AAC is Ala; R2 is OR3, NHR4, or NHNHR5; R3 is H, an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms; and R4 or R5 is independently H, OH, an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms, thereby increasing skin thickness or treating abnormal or diminished synthesis of collagen, glycosaminoglycans, proteoglycans, or elastin.