US Patent No. 10,583,169

METHYLATION-CONTROLLED J PROTEIN (MCJ) FOR TREATMENT OF LIVER DISEASE AND ALTERING MITOCHONDRIAL METABOLISM


Patent No. 10,583,169
Issue Date March 10, 2020
Title Methylation-controlled J Protein (mcj) For Treatment Of Liver Disease And Altering Mitochondrial Metabolism
Inventorship Mercedes Rincon, Burlington, VT (US)
Ketki M. Hatle, Jamaica Plain, MA (US)
Assignee University of Vermont and State Agricultural College, Burlington, VT (US)

Claim of US Patent No. 10,583,169

1. A method for treating a metabolic disease or condition in a subject, the method comprising administering to a subject in need of such treatment, an MCJ-modulating compound that decreases MCJ polypeptide activity, in an amount effective to treat the metabolic disease or condition in the subject, wherein the MCJ-modulating compound comprises an MCJ siRNA, and the metabolic disease or condition is non-alcoholic fatty liver disease, alcoholic fatty liver disease, liver steatosis, liver inflammation, hepatitis, steatohepatitis, Hepatitis C, Genotype 3 Hepatitis C, or acute fatty liver of pregnancy and is not cancer.