US Patent No. 10,557,854

CA IX—NIR DYES AND THEIR USES


Patent No. 10,557,854
Issue Date February 11, 2020
Title Ca Ix—nir Dyes And Their Uses
Inventorship Sumith A Kularatne, West Lafayette, IN (US)
Pravin Gagare, West Lafayette, IN (US)
Ananda Kumar Kanduluru, West Lafayette, IN (US)
Assignee On Target Laboratories, LLC, West Lafayette, IN (US)

Claim of US Patent No. 10,557,854

1. A compound having the formula:B-W-X-Y-Z
wherein B is a CA IX-targeted molecule is selected from the group consisting of

wherein n is 0, 1, 2, 3 . . . ; m is 0, 1, 2, 3, 4, 5, . . . and p is 0, 1, 2, 3, . . . ;
W is an extended hydrophobic residue;
X is a hydrophobic spacer;
Y is an amino acid spacer; and
Z is a NIR dye.