US Patent No. 10,525,120

METHODS AND COMPOSITIONS FOR LIVE ATTENUATED VIRUSES


Patent No. 10,525,120
Issue Date January 07, 2020
Title Methods And Compositions For Live Attenuated Viruses
Inventorship Dan Stinchcomb, Fort Collins, CO (US)
Jorge E. Osorio, Mount Horeb, WI (US)
Assignee TAKEDA VACCINES, INC., Cambridge, MA (US)

Claim of US Patent No. 10,525,120

1. A virus composition comprising:one or more live, attenuated flaviviruses; and a stabilizing composition comprising serum albumin and trehalose,
wherein the one or more live, attenuated flaviviruses consists of one or more Dengue viruses;
wherein the serum albumin is serum albumin from a vertebrate species, and is present at a concentration of 0.001 to 3.0% (w/v);
wherein the trehalose is present at a concentration of at least 15% (w/v); and
wherein the composition is capable of reducing the inactivation of the one or more live, attenuated Dengue viruses.