US Patent No. 10,512,652

USE OF CYMANQUINE COMPOUNDS AS ANTIMALARIAL AGENTS


Patent No. 10,512,652
Issue Date December 24, 2019
Title Use Of Cymanquine Compounds As Antimalarial Agents
Inventorship William E. Geiger, Williston, VT (US)
Kevin Lam, Genval (BE)
Lawrence W. Bergman, Landsdale, PA (US)
Assignee University of Vermont and State Agricultural College, Burlington, VT (US) ...

Claim of US Patent No. 10,512,652

1. A method of treatment of malaria comprising administering to an individual who has been diagnosed with and/or is suffering from malaria comprising administering to the individual a therapeutically effective amount of a composition comprising one of more compounds of the following formula:wherein:M is Mn or Re,
L is a neutral, two-electron donor ligand,
R1 is an amine-substituted alkyl group,
R2 is H, (CH2)nCH3, wherein n is 0 or any integer from 1 to 20, OMe, OEt, OPh, Ph, CHO, COMe, COPh, CH2OH, CO2H, CO2Me, CO2Et, CH2Ph, NH2, NMe2, NEt2, C6H4Me, C6H4OMe, NH2COMe, F, Cl, Br, or I; and
E is a linker moiety connecting the cyclopentadienyl moiety with the chloroquinoline moiety, wherein E is —NH(CH2)n—, —NH(CH2)nNH—, or —NH(CH2)nNH(CH2)— and n is an integer from 1 to 10.