US Patent No. 10,470,445

FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT AND IMMUNODEFICIENT RATS AND USES THEREOF


Patent No. 10,470,445
Issue Date November 12, 2019
Title Fumarylacetoacetate Hydrolase (fah)-deficient And Immunodeficient Rats And Uses Thereof
Inventorship John R. Bial, Portland, OR (US)
Elizabeth M. Wilson, Tualatin, OR (US)
Aron M. Geurts, Milwaukee, WI (US)
Assignee Yecuris Corporation, Tigard, OR (US)

Claim of US Patent No. 10,470,445

1. A genetically modified fumarylacetoacetate hydrolase (Fah)-deficient rat whose genome is homozygous for a disruption in exon 3 of the Fah gene such that the disruption results in loss of expression of functional FAH protein and decreased liver function in the rat.