US Patent No. 10,462,892

MEDICAL THERAPEUTIC APPARATUS, METHOD OF USING MEDICAL THERAPEUTIC APPARATUS, AND METHOD OF APPLYING REACTIVE GAS


Patent No. 10,462,892
Issue Date October 29, 2019
Title Medical Therapeutic Apparatus, Method Of Using Medical Therapeutic Apparatus, And Method Of Applying Reactive Gas
Inventorship Takaya Oshita, Nagareyama (JP)
Tsuyoshi Uehara, Nara (JP)
Yu Nagahara, Kyoto (JP)
Yoshishige Takikawa, Osaka (JP)
Assignee SEKISUI CHEMICAL CO., LTD., Osaka (JP)

Claim of US Patent No. 10,462,892

1. A medical therapeutic apparatus which generates plasma and blows out a reactive gas generated by the generated plasma toward a target object from an outlet,wherein a temperature of the reactive gas at a target surface positioned at a distance of 1 mm or more and 10 mm or less from the outlet is 40° C. or less, and at least one of the following requirements is satisfied: (1) a hydroxyl radical concentration is 0.1 to 300 ?mol/L, and (2) a singlet oxygen concentration is 0.1 to 300 ?mol/L,
wherein the hydroxy radical concentration is measured by a method comprising applying the reactive gas to 0.4 mL of a 0.2 mol/L solution of DMPO (5,5-dimethyl-1-pyrroline-N-oxide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a hydroxyl radical concentration of the resulting solution by electron spin resonance (ESR) method, and
the singlet oxygen concentration is measured by a method comprising applying the reactive gas to 0.4 mL of a 0.1 mol/L solution of TPC (2,2,5,5-tetramethyl-3-pyrroline-3-carboxamide) for 30 seconds with a distance from the outlet to a liquid surface of the solution being 5.0 mm, and measuring a singlet oxygen concentration of the resulting solution by electron spin resonance (ESR) method.