US Patent No. 10,428,315

BACULOVIRUS-BASED PRODUCTION OF BIOPHARMACEUTICALS FREE OF CONTAMINATING BACULOVIRAL VIRIONS


Patent No. 10,428,315
Issue Date October 01, 2019
Title Baculovirus-based Production Of Biopharmaceuticals Free Of Contaminating Baculoviral Virions
Inventorship Otto-Wilhelm Merten, Crespieres (FR)
Martin Marek, Malec (CZ)
Monique Van Oers, Renkum (NL)
Assignee GENETHON, Evry (FR)

Claim of US Patent No. 10,428,315

1. A method for the production of a biopharmaceutical product, comprising:(a) infecting a biopharmaceutical-producing insect cell with at least one baculovirus, said at least one baculovirus comprising a genome coding for said biopharmaceutical product, and
(b) maintaining the biopharmaceutical-producing insect cell under conditions such that the biopharmaceutical product is produced,
wherein the genome of said at least one baculovirus is mutated to eliminate the expression of vp1054 or wherein said biopharmaceutical-producing insect cell comprises an expression control system allowing the inactivation of vp1054.