US Patent No. 10,428,065

ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES


Patent No. 10,428,065
Issue Date October 01, 2019
Title Isoxazolyl Substituted Imidazopyridines
Inventorship Neil Anthony Pegg, Cambridge (GB)
David Michel Adrien Taddei, Nottingham (GB)
Richard Brown, Nottingham (GB)
Assignee CELLCENTRIC LTD, Cambridge, Cambridgeshire (GB)

Claim of US Patent No. 10,428,065

1. A compound which is an isoxazolyl imidazopyridine of formula (I):wherein:R0 and R, which are the same or different, are each H or C1-6 alkyl;
R9? and R9?, which are the same or different, are each H or F;
R2 and R2?, which are the same or different, are each H or C1-6 alkyl; or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group;
R3 and R3?, which are the same or different, are each H, C1-6 alkyl, OH or F;
R4 is phenyl or a 5- to 12-membered N-containing heteroaryl group and is unsubstituted or substituted;
alk is C1-6 alkylene;
R? is C1-6 alkyl;
n is 0 or 1; and
X—R1 is selected from the following structures:













or a pharmaceutically acceptable salt thereof.